评论
打印
But in the wake of the opioid crisis, perhaps the biggest worry is that loosening the reins too much on the use of ketamine and similar drugs could lead to a new abuse crisis.
但是，在阿片类药物危机之后，也许人们最大的担忧是放松对使用氯胺酮和类似药物的控制可能导致新的滥用危机。
That's why Wall Street analysts are particularly excited by Allergan's rapid-acting antidepressant, rapastinel, which is about a year behind esketamine in testing.
这就是华尔街分析人士对美国制药公司爱力根的快速抗抑郁药雷帕斯汀特别兴奋的原因，该药的测试落后于艾氯胺酮一年。
Researchers say it likely acts on the same target in the brain as ketamine, the NMDA receptor, but in a more subtle way that may avoid the disassociation side effects and abuse potential.
研究人员表示，它可能与氯胺酮（NMDA受体）在大脑中的作用相同，但效用更加微妙，可以避免解离副作用和滥用的可能性。
Studies in lab animals show the drug doesn't lead creatures to seek more of it, as they sometimes do with ketamine, says Allergan Vice President Armin Szegedi.
爱力根副总裁阿明·斯齐格迪表示，对实验室动物进行的研究表明，这种药物不会导致用药的动物成瘾，而使用氯胺酮有时则会出现这种情况。
Allergan's medicine is an IV drug, but the company is developing an oral drug.
爱力根公司的药物是一种静脉注射药，但该公司正在开发口服药物。
For its suicide study, Allergan is working hard to enroll veterans, one of the populations most affected by the recent spike in suicides, and has included several U.S. Department of Veterans Affairs medical centers as sites in the trial. veteran association
在爱力根开展的自杀研究中，他们正在努力招募退伍军人，这是受近期自杀事件激增影响最严重的人群之一，该公司已经将数个美国退伍军人事务部医疗中心列为试验场所。
More than 6,000 veterans died by suicide each year from 2008 to 2016, a rate that's 50 percent higher than in the general population even after adjusting for demographics, according to VA data.
据美国退伍军人事务部的数据显示，从2008年到2016年，每年有超过6000名退伍军人自杀身亡，即使在调整人口统计数据后，这一比例也比普通人群高50%。
"How the brain mediates what makes us who we are is still a mystery, and maybe we will never fully understand it," Szegedi says.
斯齐格迪说：“有关大脑如何调解使我们成为现实这件事情仍然是一个谜，也许我们永远不会完全理解它。”
"What really changed the landscape here is you had clinical data showing 'This really does the trick.'
“真正改变整个局面的是有临床数据显示‘这真能起作用’。
Once you find something in the darkness, you really have to figure out: Can you do something better, faster, safer?"
一旦在黑暗中发现了什么，就必须弄清楚：能够做得更好、更快、更安全吗？”
