1.horrible: when someone behaved in a very rude, unkind, or annoying way.
She's a horrible person. 她是个很糟糕的人。
I really don't like her at all. she is horrible. 我真的一点都不喜欢她，她很讨厌啊！
be horrible to somebody : 对某个人不友善。
I think I'll just leave if you're going to be horrible to me. 如果你凶我，对我态度不好，我就走！

2.unpleasant: rude or unfriendly in the way you talk to people or answer their questions.
That man in the grocery store is always so unpleasant. 超市的那个人总是很不友善。
be unpleasant to somebody: 对某人态度不好
You shouldn't have been so unpleasant to her. She was only trying to help.你不该对她态度那么不好的，她也只是想要帮忙而已。

3.nasty: someone who is nasty has a very unpleasant character and is often unkind to people.
My first boss was a really nasty person. 我的第一个老板很让人讨厌。
I'd avoid him if I were you. He can be quite nasty. 如果我是你，我就避开他。他很让人讨厌。

4.obnoxious: rude and offensive, especially deliberately.
You're behaving like a spoiled obnoxious child. 你现在就像个被宠坏的没礼貌的小孩。

5.mean: cruel or not kind.
Don't be so mean to her. 别对她这么刻薄嘛
That's really mean. 这也太过分了吧。

6.creep: someone who you dislike because they are unpleasant and behave in a way that makes you feel uncomfortable.
He didn't say that, did he? What a creep! 天哪他真的这么说了吗？这人真是讨厌！
Get out of here you little creep! You make me sick! 快走开你这个讨厌鬼！我看见你就想吐。