As always, however, nothing was quite as straightforward as such a breezy description makes it sound. Meteorites are not abundant and meteoritic samples not especially easy to get hold of. Moreover, Brown's measurement technique proved finicky in the extreme and needed much refinement. Above all, there was the problem that Patterson's samples were continuously and unaccountably contaminated with large doses of atmospheric lead whenever they were exposed to air. It was this that eventually led him to create a sterile laboratory—the world's first, according to at least one account.

It took Patterson seven years of patient work just to assemble suitable samples for final testing. In the spring of 1953 he traveled to the Argonne National Laboratory in Illinois, where he was granted time on a late-model mass spectrograph, a machine capable of detecting and measuring the minute quantities of uranium and lead locked up in ancient crystals. When at last he had his results, Patterson was so excited that he drove straight to his boyhood home in Iowa and had his mother check him into a hospital because he thought he was having a heart attack.