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If at some point the beta cells fail to release enough insulin to control glucose levels.
当到达了某一个临界点时β细胞无法释放出足够的胰岛素去控制葡萄糖水平时
That's the beginning of diabetes called pre-diabetes and then it evolves to diabetes.
糖尿病就发生了我们称之为"前糖尿病"它可能发展成为糖尿病
And so in fact insulin sensitivity and the beta cell response have to be compensating for each other.
所以事实上胰岛素敏感性和β细胞的反应是互补的
And remain...and the product of the two which is the disposition index has to remain constant so if for some reason.
而作为两者平衡的结果就是葡萄糖稳态指数应该保持恒定如果出于某种原因
You become less insulin sensitive like a women becomes pregnant or you are taking a drug.
你的胰岛素敏感性降低了比如怀孕妇女或者你正在服用某种药物
Or you put on some weight as long as your beta cells are able to up regulate the production of insulin.
或者你的体重增加了那么只要你的β细胞能够向上调整胰岛素的分泌水平
Your diabetes risk will not change but if in fact your beta cells cannot accommodate that extra load.
那么你患糖尿病的风险将不会出现变化但如果事实上你的β细胞不堪重负
Then this hyperbola will move to the origin and your diabetes risk will be increased so in this first study of Dr. Spiegel.
那么这条抛物线将会回到最初的位置你患糖尿病的风险便增加了在斯彼格博士的第一项研究中
She noticed a decrease of insulin sensitivity with sleep loss 5 days of 4 hours in bed However, the beta cells instead of compensating.
她注意到睡眠缺失会造成胰岛素敏感度的下降也就是连续5天 每天只睡4个小时然而 β细胞不仅没有释放出更多的胰岛素
And releasing more they actually release significantly less and therefore, the disposition index.
去进行弥补释放出的胰岛素反而大幅度减少了因此 葡萄糖稳态指数
This marker of diabetes risk inversely related to diabetes risk so the lower the disposition index.
也就是糖尿病风险的标识与糖尿病风险成反比葡萄糖稳态指数越低
The higher the diabetes risk was significantly changed Three years after that.
糖尿病风险越大因此这些人的葡萄糖稳态指数发生了显着变化三年之后
Nedeltchava team did another study where those were overweight, mid-age individuals 14 nights of 5.5 hours in bed is compared.
内德尔查韦研究团队开展了另一项研究研究对象是体重超重的中年人比较他们在连续14天每晚只睡5.5个小时的状态
