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You can see the beginnings of a kind of J shape here
大家可以看出曲线基本呈现一个J的形状
but other groups are not significant
但其他人群的情况则不那么显着
So why this might be the case?
为什么会出现这样的情况?
So here are some data we presented at APS here
这里是APS的一些数据
the papers and submissions right now
根据会议提交上来的论文
looking at information as potential pathways
这些信息显示了导致肥胖症的潜在途径
So do short and long sleepers
睡眠时间过短和睡眠时间过长
have increased inflammation?
是否会增加炎症的发生几率?
So here are some unadjusted and adjusted data
这里有一组NHNES的调整前和调整后的数据
also from NHNES looking at
查看睡眠时间长短
sleep duration categories in CRP
对CRP的影响
which is an important inflammatory marker
CRP是一个重要的炎症标识物
You can see
大家可以看出
after adjusting for all these typical covariates
在调整了所有典型的协变量
and a couple of new ones
以及一些新的变量之后
that you do have elevation in short and long sleep
短期睡眠和长期睡眠都有了提升
you actually plot it squared turns
这里还出现了直角变化
to actually show a significant U shape
基本上形成了一个显着的U型
I also do want to know that
我还想知道的是
we included in here variables
我们加入的变量
that could potentially come for insomnia, sleep apnea
对失眠和睡眠呼吸障碍有潜在的影响
So a lot of these population studies looking at sleep duration
所以针对人们睡眠时间的这些研究
are probably confounded by lots of undiagnosed sleep disorders
很可能还涉及到很多未被确诊的睡眠障碍
So we try to account for some of that variants there
所以我们也试图对这些变量进行解释
So even still we do have elevations there
所以尽管在这里出现了上升趋势
So there have been a number of studies
但仍然有很多研究
that have looked at this potential pathway
关注的是潜在的致病途径
Sleep restriction in the laboratory
在实验室中通过睡眠限制试验发现
have shown elevations of TNFa and IL-6
TNFa和IL-6都出现了上升
Short sleep duration in the population
样本人群的睡眠时间短
so this is a little more relevant to the general populations
这样一般人群中的这些指标
and the stuff we are talking about
都会出现上升趋势
