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even before the onset of menopause
出现的睡眠问题
So when we look at hot flushes and sleep
我们开始注意到潮热和睡眠问题
we are back in the 88 when I was in Seattle
是在1988年的西雅图
We looked at women who were peri-menopausal
我们研究的对象是围绝经期妇女
who had the symptoms and didn't have symptoms
她们有的已经出现了症状 有的则没有
In the sleep lab
在睡眠实验室
there was really very little difference
她们的多导睡眠图所反映出的客观数据
in their objective polysomnographic sleep
并没有太大的差别
The difference between wake time of 10% and 13%
分别为10%和13%
is almost nothing
它们之间的差别几乎可以忽略不计
We've had other people who replicated
有的研究人员不相信我们的研究结果
that a few years later didn't believe us
他们几年之后重复了我们的试验
and then looked at other women flushers and non-flushers
对存在潮热和没有潮热的妇女进行了研究
and there's just only about 5% difference
她们夜间醒来的比例
between their wake time during the night
差别也只有5%
so not enough to explain all the complaints
这个差别不足以说明
about their insomnia during menopause
绝经期失眠的原因
Hormone replacement therapy actually
激素替代疗法事实上
helped reduce the symptom experience and complaints
能够降低患者的症状
but it had no effect on sleep changes and the stages
但对睡眠各阶段的构成
or the architecture of sleep
以及睡眠结构没有任何的影响
Women we did learn from these are CT...
我们从CT上得知
hormone replacement therapy studies was that
激素替代疗法研究显示
there is a very low incidence of periodic limb movements during sleep
这个年龄段的女性
for women in this age group
睡着时的间歇性肢体活动并不多
and a low incidence of sleep disordered breathing
睡眠呼吸障碍的发生率也不高
we see quite higher incidence of this in man
而男性这种情况比较多
And it is thought that progesterone
人们认为孕酮
was protective of breathing issues for women
可以保护女性不会出现睡眠呼吸障碍
and once menopause hit
但一旦进入绝经期
women would have similar rates
女性的睡眠呼吸障碍发生率
of sleep disorder breathing and sleep apnea
和男性一样高
but that doesn't seem to be the case
但实际情况并非如此
It's much more associated with obesity
造成睡眠呼吸障碍的原因更多的是肥胖
than with hormones
而不是激素
Freedman and Roehrs in Detroit
来自底特律的弗里曼和罗尔斯
actually didn't believe anybody either
也不相信别人的研究结果
They did their own study of symptomatic midlife women
他们亲自对中年妇女的症状进行了研究
and they were scratching their heads after this study
研究结果也让他们困惑不已
But they did point out that with very good methodology
但他们确实提供了一种很好的研究方法
women were having about 5 hot flushes during the night
女性每晚平均出现5次潮热
and they range from 1 to 18
最少1次 最多18次
