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How many of you have your flu shot already this year?
你们有多少人今年已经注射过流感疫苗了?
Great
好极了
Did you get a good night sleep before you had a flu shot?
你们在注射之前睡了个好觉吗?
Or after that flu shot?
注射之后睡个好觉了吗?
There's a lot of data now that would indicate
现在有很多研究数据显示
that if you are not getting sleep
如果你没有睡好
a study of a healthy young man
对健康的年轻人的研究显示
they have deprived them of sleep to 4 hours
如果他们连续4个晚上
a night for 4 nights
只睡4个小时
then gave them the flu shot
然后再接受流感疫苗注射
The other group sleeps normally
而另一组睡眠时间正常
and 10 days later
十天之后
they have much lower titer to their flu shot response rate
和正常睡眠的小组相比
than the young healthy men who got the normal sleep time
睡眠不足的小组血液中的流感抗体要低得多
This was in 2002
这是2002年的研究结果
It's been replicated in a fair number
这个试验被重复了很多次
of other types of studies
选择的疫苗各有不同
including hepatitis A vaccine
包括甲肝疫苗
Let me show you the results
我给大家看一看结果
These are a little easier to interpret
相对于其他疫苗或免疫方面的问题
than some of the other vaccination and immunization issues
这个数据要容易理解得多
but if both groups are sleeping fine
如果两个小组的睡眠情况都正常
they get their flu shot
然后他们都接受了流感疫苗
the group that actually had good night sleep
那么接受疫苗注射之后
after the vaccine
睡了好觉的小组
had a much higher titer for Hep A vaccine
甲肝抗体的浓度
than the group that was left awake and kept awake
要高于注射流感疫苗之前
the whole night before their flu shot
整晚没有睡觉的小组的浓度
So it's a very critical issue with cytokine metabolism
所以睡眠对细胞激素的代谢
going on in sleep
起到了非常重要的作用
and sleep is very important for immune function
睡眠对免疫功能至关重要
Now I've actually looked at sleep in pregnancy
我还研究了怀孕时的睡眠
This was...we should talk about publication problems
我要讲讲这方面论文的发表问题
because I was publishing on sleep and pregnancy
我本来打算发表一篇睡眠和怀孕的关系的文章
and I sent this to a couple of OB journals
我把文章投给了一份产科方面的学报
and they said
结果他们说
I'm sorry
对不起
we don't have anybody
我们这里没有人能够审阅
who can review any papers on sleep for women
女性睡眠问题的文章
Could you suggest them review yours
你能不能建议他们审阅
It was very difficult to get this published
所以文章很难发表
But we looked at women during their third trimester
我们研究了孕妇在临产前3个星期
