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1.lead to 导致；通向
This can lead to significant distress, but have no fear!
这可能导致巨大的压力，但是不要害怕！
I believe that his friends, above all Halifax, came to the conclusion that he must be rooted out of the life he was leading at Trinity which must soon lead to decay of mind and health.
我相信他的朋友们，首先是哈利法克斯得出这样的结论：他必须从在三一学院沿循的生活中拔出脚来，否则它必定很快会导致精神和健康的衰落。
2.open up 打开；开发
The doctor opened up his stomach to get at the source of the trouble.
医生给他的胃开了刀，以便找出病根。
He decided to open up a business in the city.
他决定在城里开一家商店。
